Protein Collections kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8.SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and targeting ALK3 for ubiquitin-mediated degradation.Here, we identify a deubiquitylating e
By its very nature, agriculture is a risky endeavor.Farmers not only face natural threats from WALLET pests, plant disease, and inclement weather, but many must also worry about fluctuating input costs, uncertain prices for their output, and, ultimately, their ability to repay debts and support their families.The growing incidence of extreme weathe
Machine learning methods for protein function prediction are urgently needed, especially now that a substantial fraction of known sequences remains unannotated despite the extensive use of functional assignments based on sequence similarity.One major bottleneck supervised learning faces in protein function prediction is the structured, multi-label
In order to achieve the Sustainable Development Goals (SDG), it is imperative to Donation ensure the safety of drinking water.The characteristics of each drinkable water, encompassing taste, aroma, and appearance, are unique.Inadequate water infrastructure and treatment can affect these features and may also threaten public health.This study utiliz